At-home initial screen (new tick bite, no access to a clinic)

At-Home Lyme Antibody Test – broad Borrelia antibody screen for early immune response.

Best for: Early and evolving infections

Lyme ImmunoBlot IgM & IgG – more sensitive than standard Western Blot for early Lyme.

PCR Panel – detects Borrelia burgdorferi, B. miyamotoi, Babesia microti, Bartonella henselae, Anaplasma phagocytophilum DNA.

Tick-Borne Relapsing Fever ImmunoBlot – helpful if traditional Lyme tests are negative but symptoms persist.

Babesia FISH – detects active parasitemia (useful early).

Bartonella or Rickettsia soon after exposure

Bartonella ePCR™ – multi-draw PCR that can pick up bacteremia in the early phase.

Rickettsia PCR Panel – if patient presents with acute fever and rash.

Broad antibody and peptide-based screen

Lyme Disease Panel (Borrelia species–specific peptides)

Co-Infection Panel (Bartonella, Babesia, Ehrlichia, Anaplasma, Rickettsia, etc.)

Tickborne 2.0 or Total Tickborne Panel (covers multiple vector pathogens)

Early-stage microscopic confirmation

Borrelia PCR + Microscopy Combo – detects spirochetes directly from blood or tissue.

Co-Infection PCR Panel – screens Babesia, Bartonella, Ehrlichia, and Rickettsia.

(often insurance-covered, first-line for new infections):

The Panel measures autoimmune antibodies against brain targets like Dopamine D1/D2 receptors, Lysoganglioside, and Tubulin, linked to neuropsychiatric symptoms such as tics, OCD-like behaviors, ADHD, anxiety, and depression. Elevated levels suggest symptoms may stem from infection-triggered autoimmune processes, aiding treatment decisions. Up to 60% of patients with neurological and psychiatric disorders worldwide are treatment-resistant, possibly due to undiagnosed infection-driven immune dysfunction from diseases like Lyme & Coinfection.

FRAT® (Folate Receptor Antibody Test) detects Folate Receptor Autoantibodies (FRAs) in blood. In a study of 47 PANS/PANDAS patients, 63.8% tested positive. Infection-induced PANS is a neuropsychiatric condition linked to vector illness. FRAT® uniquely detects both blocking and binding FRAs, as noted in the New England Journal of Medicine. FRA presence disrupts folate (vitamin B9) transport to the brain and CSF, affecting growth and neurological function.

Mitochondrial testing may be beneficial for individuals experiencing chronic health concerns affecting three or more body systems: This could include combinations of symptoms such as muscle weakness, digestive issues, and neurological/behavioral problems.

Chronic infections and mitochondrial dysfunction are closely linked in a two-way relationship, contributing to conditions like encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID. Pathogens like Vector Illness can directly damage mitochondria and manipulate cell metabolism for their benefit.

Neuroimaging (MRI, SPECT): Assesses brain and nerve changes caused by infection.

EEG or nerve studies: Evaluate brain and nerve function.

Comorbidity & Systemic Testing: HPA axis / adrenal function: Cortisol, ACTH, and related hormone panels to check stress-response system.

Cardiac evaluation: ECG, echocardiogram, or troponin tests if heart involvement is suspected.

Inflammatory markers: ESR, CRP, Immunoglobulin and cytokine panels to assess immune competence & systemic inflammation.

Autoimmune panels: ANA, ENA, anti-neuronal antibodies to rule out overlapping autoimmune conditions.

Why this matters: Lyme can affect multiple systems, and chronic or late-stage infection may trigger or worsen inflammation, autoimmune reactions, hormonal imbalance, or heart issues. Comprehensive testing helps doctors tailor treatment to your whole-body health, not just the infection.