At-Home Lyme Antibody Testing for several species of: Lyme Borrelia, Babesia, and Bartonella.

No Need for a Physician’s Order

Best for: Early and evolving infections.

Covered by Medicare part B. Not covered by commercial health insurance

FISH (fluorescence in-situ hybridization) for Babesia and Bartonella species. A positive test proves current infection.

 Immunoblot Antibody Tests -- For Borrelia, Babesia, and Bartonella (BBB) species. IgM for early infection, IgG for chronic infection. More sensitive and specific than Western Blot or other antibody tests. A positive antibody test proves past infection. It does not necessarily prove current infection. Combine FISH and antibody testing for greater sensitivity.

PCR (polymerase change reaction) -- Detects DNA of BBB and other tick-borne pathogens. A positve test proves current infection. A negative test does not rule out current infection (i.e., PCR testing has a low sensitivity).

Physician ordered; self-pay, with possible insurance reimbursement

TLab offers direct-detection testing for:

• Borrelia (Lyme) — RNA FISH / molecular imaging

• Bartonella — RNA FISH / molecular imaging

• Babesia — RNA FISH / molecular imaging

• Biofilm / blood-cell abnormalities — imaging-based assessment

• PCR/co-infection testing, including Ehrlichia and Anaplasma.

Tlab specializes in direct detection of organisms/pathogen material rather than relying only on antibodies

Not covered by health insurance

 Bartonella 4-species IFA serology (antibodies). Best available Bartonella antibody test

BBB Direct Detect Digital PCR -- for all three parasites. Triple draw available to increase sensitivity.

Lyme Urine Nanotrap -- Detects Lyme antigens in the urine, proving current infection

(often insurance-covered, first-line for new infections, sometimes used in relapse/remitting presentations.

PCR and Antibody Tests: Useful only for acute and chronic Lyme disease, for acute babesiosis caused by Babesia microti or duncani, and for acute bartonellosis caused by Bartonella henselae and quintana. No tests for chronic babesiosis or bartonellosis.

The Panel measures autoimmune antibodies against brain targets like Dopamine D1/D2 receptors, Lysoganglioside, and Tubulin, linked to neuropsychiatric symptoms such as tics, OCD-like behaviors, ADHD, anxiety, and depression. Elevated levels suggest symptoms may stem from infection-triggered autoimmune processes, aiding treatment decisions.

FRAT® (Folate Receptor Antibody Test) detects Folate Receptor Autoantibodies (FRAs) in blood. In a study of 47 PANS/PANDAS patients, 63.8% tested positive. "PANS is a neuropsychiatric illness linked to infections, including vector-borne infections." FRAT® uniquely detects both blocking and binding FRAs, as noted in the New England Journal of Medicine. FRA presence disrupts folate (vitamin B9) transport to the brain and CSF, affecting growth and neurological function.

Mitochondrial testing may be beneficial for individuals experiencing chronic health concerns affecting three or more body systems: This could include combinations of symptoms such as muscle weakness, digestive issues, and neurological/behavioral problems.

Chronic infections and mitochondrial dysfunction are closely linked in a two-way relationship, contributing to conditions like encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID. "Vector-borne parasites cause inflammation which produces mitochondrial dysfunction".

Neuroimaging (MRI, SPECT, PET/MRI): Assess anatomical and functional brain changes caused by infections and inflammation.

EEG or nerve studies: Evaluate brain and nerve function.

‍ ‍Comorbidity & Systemic Testing

HPA axis / adrenal function: Cortisol, ACTH, and related hormone panels to check stress-response system.

Cardiac evaluation: ECG, echocardiogram, or troponin tests if heart involvement is suspected.

Inflammatory markers: ESR, CRP, Immunoglobulin and cytokine panels to assess immune competence & systemic inflammation.

Autoimmune panels: ANA, ENA, anti-neuronal antibodies to rule out overlapping autoimmune conditions.

Why this matters: Lyme, Bartonella, and Babesia infections can affect multiple systems. They promote inflammation in various tissues and organs and can cause autoimmune diseases. They can cause endocrine, cardiac, gastrointestinal, rheumatological, and neurological dysfunction and disease. Comprehensive testing helps doctors tailor treatment to your whole-body health, not just the infection.